Blar i forfatter "Ajayi, Clement"

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    • Determinants of Staphylococcus aureus Colonization and Infection. “Exploring the Role of Cell Wall Anchored Proteins in Adhesion and Immune Evasion” 

      Ajayi, Clement (Doctoral thesis; Doktorgradsavhandling, 2018-11-09)
      Staphylococcus aureus is an efficient human colonizer and pathogen. S.aureus' ability to colonize and/or cause infections in humans is due to its expression of many virulence factors. These virulence factors aid the bacterium in adhering, invading and evading the host´s immune defences. This study focused on exploring the role of two cell wall anchored proteins: Serine-aspartate containing protein ...

    • Exploring differentially expressed genes of Staphylococcus aureus exposed to human tonsillar cells using RNA sequencing 

      Bastakoti, Srijana; Ajayi, Clement; Julin, Kjersti; Johannessen, Mona; Hanssen, Anne Merethe (Journal article; Tidsskriftartikkel, 2023-07-12)
      Background - The nose and the throat are the most predominant colonizing sites of Staphylococcus aureus, and colonization is a risk factor for infection. Nasal colonization is well described; however, we have limited knowledge about S. aureus throat colonization. The main objective of this study was to explore differentially expressed genes (DEGs) in S. aureus throat isolate TR145 exposed to human ...

    • Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers 

      Ajayi, Clement; Åberg, Espen; Askarian, Fatemeh; Sollid, Johanna U Ericson; Johannessen, Mona; Hanssen, Anne Merethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-16)
      <p><i>Background</i>: <i>Staphylococcus aureus</i> cell wall anchored Serine Aspartate repeat containing protein D (<i>sdrD</i>) is a member of the microbial surface component recognising adhesive matrix molecules (MSCRAMMs). It is involved in the bacterial adhesion and virulence. However the extent of genetic variation in <i>S. aureus sdrD</i> gene within isolates from healthy carriers are not ...

    • The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells 

      Askarian, Fatemeh; Ajayi, Clement; Hanssen, Anne-Merethe; Van Sorge, Nina M.; Pettersen, Ingvild; Diep, Dzung Bao; Sollid, Johanna U. Ericson; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-29)
      <i>Staphylococcus aureus</i> is known as a frequent colonizer of the skin and mucosa. Among bacterial factors involved in colonization are adhesins such as the microbial surface components recognizing adhesive matrix molecules (MSCRAMMs). Serine aspartate repeat containing protein D (SdrD) is involved in adhesion to human squamous cells isolated from the nose. Here, we identify Desmoglein 1 ...

    • Serine-aspartate-repeat protein D Increases Staphylococcus aureus Virulence and Survival in Blood 

      Askarian, Fatemeh; Uchiyama, Satoshi; Valderrama, J. Andrés; Ajayi, Clement; Sollid, Johanna U. E.; Van Sorge, Nina M.; Nizet, Victor; van strijp, Jos A. G.; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Staphylococcus aureus expresses a panel of cell wall-anchored adhesins, including proteins belonging to the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (SdrD), which serve key roles in colonization and infection. Deletion of sdrD from S. aureus subsp. aureus strain NCTC8325-4 attenuated bacterial survival ...